Peyronie’s Disease: Causes, Symptoms, and Treatment Options

Introduction to Peyronie’s Disease

The onset of fibrous scar tissue, or plaque, inside the penis, is a defining feature of Peyronie’s disease. During erections, this plaque may cause the penis to bend or curve, which may cause pain, discomfort, and even problems with sexual function. While Peyronie’s disease is not uncommon, many men may be unfamiliar with its symptoms and Peyronies disease treatment options.

What Causes Peyronie’s Disease?

  • Trauma: One of the primary causes of Peyronie’s disease is trauma or injury to the penis. This trauma can occur during sexual activity, athletic activities, or accidents that result in bending or twisting of the penis.
  • Genetics: According to some studies, Peyronie’s disease may be influenced by heredity since some people may be more likely than others to generate aberrant scar tissue in response to inflammation or injury.
  • Age and Health Factors: Men over 40 and those with specific underlying medical diseases, such as diabetes, hypertension, or connective tissue abnormalities, are more likely to develop Peyronie’s disease.

Symptoms of Peyronie’s Disease

  • Penile Curvature: The most common symptom of Peyronie’s disease is a noticeable curvature or bend in the penis during erections. This curvature may be mild or severe and can cause discomfort or difficulty with sexual intercourse.
  • Pain or Discomfort: Some men with Peyronie’s disease may experience pain or discomfort in the penis, particularly during erections or sexual activity.
  • Erectile Dysfunction: Erectile dysfunction, or the inability to get or sustain an erection strong enough for sexual activity, can occasionally result from Peyronie’s disease.
  • Shortening of the Penis: In addition to curvature, Peyronie’s disease can sometimes result in shortening of the penis due to the presence of scar tissue.

Diagnosis and Evaluation

  • Physical Examination: A healthcare provider can usually diagnose Peyronie’s disease based on a physical examination of the penis and a discussion of symptoms.
  • Medical History: A detailed medical history, including any past injuries or surgeries involving the penis, can help confirm the diagnosis.
  • Imaging Tests: Certain imaging procedures, such magnetic resonance imaging (MRI) or ultrasound, can be used to assess the amount of penile curvature and the presence of scar tissue.

Treatment Options for Peyronie’s Disease

  • Medications: Oral medications such as collagenase clostridium histolyticum (Xiaflex) may be prescribed to help break down the plaque associated with Peyronie’s disease and reduce penile curvature.
  • Penile Traction Devices: Traction therapy involves the use of specialized devices worn on the penis to gradually stretch and straighten the tissue affected by Peyronie’s disease.
  • Injections: Medication injected straight into the plaque has the potential to lessen penile curvature and ease the scar tissue.
  • Surgery: To relieve penile curvature and restore sexual function, surgical procedures such as penile plication or grafting may be required in severe cases of Peyronie’s disease that do not respond to previous therapies.

Lifestyle and Home Remedies

  • Healthy Lifestyle: The risk of problems from Peyronie’s disease can be decreased by keeping a healthy weight, exercising often, abstaining from tobacco use, and limiting alcohol use.
  • Use of Lubricants: Using lubricants during sexual activity can help reduce friction and discomfort associated with penile curvature.
  • Communication: Open and honest communication with sexual partners about Peyronie’s disease and its impact on sexual function can help alleviate anxiety and improve intimacy.


Peyronie’s disease can have a significant impact on a man’s quality of life, affecting both physical and emotional well-being. However, with early diagnosis and appropriate treatment, many men with Peyronie’s disease can experience improvements in symptoms and sexual function. By understanding the causes, symptoms, and treatment options for Peyronie’s disease, individuals affected by this condition can make informed decisions about their healthcare and take steps to manage their symptoms effectively.